Kicking off adaptive immunity: the discovery of dendritic cells
نویسنده
چکیده
In 1973, Ralph Steinman and Zanvil Cohn discovered an unusual looking population of cells with an unprecedented ability to activate naive T cells. Dubbed "dendritic cells," these cells are now known as the primary instigators of adaptive immunity.
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تولید سلول های دندریتیک مهاری و سلول های شبه ماکروفاژی با استفاده ترکیبی از فاکتورهای بلوغ
Background and purpose: As professional antigen- presenting cells, dendritic cells are a bridge between innate and adaptive immunity by stimulating T lymphocytes. Recent research has demonstrated the extra ability of the myeloid cells plasticity into different cells in response to environmental stimuli. In the present study, the effect of using combination maturation factors (MCM, TNF-α, poly (...
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The 2011 Nobel Prize in Physiology or Medicine was awarded to Dr Jules A. Hoffmann and Dr Bruce A. Beutler for their discoveries of the role of Toll-like receptors (TLRs) in innate immunity and to Dr Ralph M. Steinman for his discovery of dendritic cells and their role in adaptive immunity. These discoveries have had a tremendous impact on our field. A recent article by Chtarbanova and Imler in...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 203 شماره
صفحات -
تاریخ انتشار 2006